ABSTRACT
Objective To investigate the association between a few single nucleotide polymorphisms(SNPs) in Fc receptor like 3 and ankylosing spondylitis(AS) in Hah nationality of China patients.Methods One hundred and sixty AS patients along with one hundred and seventy healthy controls were included in the study. SNPs of FcRL3-1 (rs0158440), FcRL3-2 ( rs2225828 ), FcRL3-3 ( rs7528684 ),FcRL3-4(rs11284799), FcRL3-5(rs945635), FcRL3-6(rs3761959), FcRL3-7 (rs2210913), FcRL3-8 (ra2282284) and FcRL3-9 (rs2282283) in FcRL3 gene were genotyped by MALDI-TOF technology. Haplotypes were estimated using PHASE v2.1 software. Results The frequency of FcRL3-1-1651C, FcRL3-3-169C, FcRL3-6 Intron3A and FcRL3-7 Intron3A alleles in AS patients were significantly increased and the frequency of FcRL3-2-641C, FcR-L3-4-110A and FcRL3-9 Intron15A were significantly increased compared with healthy controls. The frequency of FcRL3-1→9 CTCGCAAAA, CCCGGGGAA, CCCGCAAAC and CTCGCAAAC haplotypes were significantly increased and the frequency of FcRL3-1→9CCTGGGAA and TCCACAAGA haplotypes were significantly decreased compared with healthy controls. Conclusion These results suggest that FcRL3 may be associated with AS in Han nationality of China.
ABSTRACT
Objective To investigate the association between a few single nucleotide polymorphisms (SNPs)in Fc receptor like 3(FcRL3)and rheumatoid arthritis(RA)in Han nationality of Anhui patients.Methods One hundred and forty RA patients along with one hundred and eighty-seven healthy controls were included in the study.SNPs of FcRL3-1(rs0158440),FcRL3-2(rs2225828),FcRL3-3(rs7528684).FcRL34(rs11284799),FcRL3-5(rs945635),FcRL3-6(rs3761959),FcRL3-7(rs2210913),FcRL3-8(rs2282284)and FcRL3-9(rs2282283)in the FcRL3 gene were genotyped by MALDI-TOF technology.Haplotypes were estimated using PHASE v 2.1 software.Results The frequency of FcRL3-3-1 69C alleles in RA patients was significantly increased compared with healthy controls(X~2=7.348,P=0.007,OR=1.558,CI:1.130～2.150).The decreased compared with healthy controls.ConclusionFcRL3 may be associated with RA susceptibility in Anhui Han population.